Detailed view for PVX_093645

Basic information

TDR Targets ID: 269936
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 9.6608 | Length (AA): 3576 | MW (Da): 397611 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01593   Flavin containing amine oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
400 943 2h94 (A) 172 829 14.00 0 1 -0.36 0.87
1140 1461 1b37 (A) 147 463 18.00 0 0.77 0.04 1.39
197 313 2kh2 (B) 3 138 33.00 0.48 0.23 0.224618 -0.44
585 773 2dw4 (A) 242 427 31.00 0.00000043 0.75 0.0787523 2.14
590 1062 2vvm (A) 1 487 13.00 0 1 0.148771 0.63
621 1058 3kve (A) 32 482 18.00 0 1 0.189983 0.62
623 660 4i59 (A) 32 69 55.00 0.1 0.98 0.580526 0.73
625 872 3i6d (A) 8 286 30.00 0.035 0.97 0.0832512 1.78
1092 1570 4gut (A) 363 820 17.00 0 0.86 0.0914485 0.58
3184 3360 2i1k (A) 303 497 14.00 0.56 0.07 0.121997 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_163914)

Species Accession Gene Product
Plasmodium berghei PBANKA_1228300   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0801900   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0117000   reductase, putative
Plasmodium vivax PVX_093645   hypothetical protein, conserved
Plasmodium yoelii PY02606   amine oxidase, flavin-containing, putative
Schistosoma japonicum Sjp_0122970   hypothetical protein
Schistosoma japonicum Sjp_0128780   Conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0042 0.2805 0.5
0.0063 1 0.5
0.0108 1 0.5
0.0048 0.6551 0.6354
0.0064 1 0.5
0.0042 0.5 0.5
0.0478 0.2943 0.399
0.0041 1 0.5
0.011 0.3084 0.5
0.0217 1 1
0.0085 1 0.5
0.0087 0.3247 0.5
0.0131 0.5 0.5
0.0177 0.4028 1
0.0272 1 0.5
0.0109 1 0.5
0.0025 0.4128 0.5
0.0262 1 0.5
0.0439 0.3516 0.5
0.0255 0.6236 0.5
0.0086 0.5 0.5
0.0063 1 0.5
0.0135 0.4325 0.5
0.0239 0.2732 0.5
0.0262 1 0.5
0.0064 1 0.5
0.0419 1 0.5
0.0023 0.5 0.5
0.0023 0.5 0.5
0.0282 0.5 0.5
0.013 1 0.5
0.0065 1 0.5
0.0137 0.7284 0.5
0.0051 1 1
0.0153 1 0.5
0.0062 1 0.5
0.014 0.9532 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_093645 (Plasmodium vivax), hypothetical protein, conserved
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